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Ohio had three city-regions in the top 30 biotech locations in the country, with Cleveland-Akron ranked #20, Columbus #22, and Cincinnati #28.The overall economic impact of the bioscience industry in Ohio, including healthcare, amounted to 8.2 billion in 2007, representing 15.7% of Ohio's economic output.Boeing's Central Ohio Aerospace and Technology Center in Heath is a venture amongst five of the top 10 U. defense contractors, including Atlantic Inertial Systems, Honeywell, Kearfott, Northrop-Grumman, L3 Communications, and Raytheon, which is also the headquarters of the Air Force Metrology and Calibration Program Office.RTI International Metals's location in Niles produces titanium used in every France-based Airbus aircraft.In 2013, Ohio was ranked in the top ten states for best business climate by Site Selection magazine, based on a business-activity database.

A new report by the Quantitative Economics and Statistics Practices (QUEST) of Ernst & Young in conjunction with the Council On State Taxation (COST), ranks Ohio third in the nation for friendliest tax environment.Wright-Patterson Air Force Base, located in Dayton, and partially named for the Wright Brothers from Ohio who are generally credited with inventing the airplane, employs 27,400 residents.The Air Force estimates that Wright-Patterson’s annual economic impact on the Dayton region is .1 billion.Major manufacturing employers in the state include AK Steel, Timken, and Honda. exports in 2009, with top destinations being Canada at .2 billion, followed by Mexico, China, the United Kingdom, Greece, Brazil, Japan, Germany, France, and Australia.In 2007, foreign-based companies employed 229,500 of Ohio's citizens, led by Japan, the United Kingdom, Germany, France, and Switzerland. As of 2010, Ohio was ranked #6 in the nation for Fortune 500 companies with 23, including Cardinal Health (#17), Procter & Gamble (#22), Kroger (#23), Macy's (#103), Nationwide Insurance (#118), Goodyear Tire and Rubber (#141), Progressive Insurance (#161), American Electric Power (#172), Eaton Corporation (#194), and Owens Corning (#432).

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